| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Tyler Stephenson | C | Cin | 28 | |
| Luis Arraez | 1B | SD | 28 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Ty France | 1B | Min | 30 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| CJ Abrams | SS | Was | 24 | |
| Adael Amador | SS (2B) | Col | N/A | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Kyle Farmer | SS (2B) | Col | 34 | |
| Nolan Arenado | 3B | StL | 34 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Noelvi Marte | 3B | Cin | 23 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Heston Kjerstad | OF | Bal | 26 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Taylor Ward | OF | LAA | 31 | |
| James Wood | OF | Was | 22 | |
| Jack Flaherty | SP | Det | 29 | |
| Clay Holmes | SP | NYN | 32 | |
| Jack Leiter | SP | Tex | N/A | |
| Dustin May | SP | LAD | 27 | |
| Max Meyer | SP | Mia | 26 | |
| Carlos Rodon | SP | NYA | 32 | |
| Joe Ryan | SP | Min | 28 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Ryan Weathers | SP | Mia | 25 | March 27, 2025:15 Day IL |
| Bryan Woo | SP | Sea | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Ryan Helsley | RP | StL | 30 | |
| Kenley Jansen | RP | LAA | 37 |