| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| J.T. Realmuto | C | Phi | 34 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Michael Toglia | 1B | Col | 26 | |
| Luis Garcia | 2B | Was | 24 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Andrés Gimenez | 2B | Tor | 26 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Francisco Lindor | SS | NYN | 31 | |
| Geraldo Perdomo | SS | Ari | 25 | |
| Junior Caminero | 3B | TB | 21 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Ryan McMahon | 3B | Col | 30 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Jordan Beck | OF | Col | 24 | |
| JJ Bleday | OF | Oak | 27 | |
| Jarren Duran | OF | Bos | 28 | |
| Lars Nootbaar | OF | StL | 27 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| MacKenzie Gore | SP | Was | 26 | |
| Sonny Gray | SP | StL | 35 | |
| Michael King | SP | SD | 29 | |
| Seth Lugo | SP | KC | 35 | |
| Kodai Senga | SP | NYN | 32 | |
| Shane Smith | SP | ChA | N/A | |
| Jeffrey Springs | SP | Oak | 32 | |
| José Alvarado | RP | Phi | 29 | |
| Felix Bautista | RP | Bal | 29 | |
| Kyle Finnegan | RP | Was | 33 | |
| Robert Suarez | RP | SD | 34 |