| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Sean Murphy | C | Atl | 30 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Bryce Harper | 1B | Phi | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Ozzie Albies | 2B | Atl | 28 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| J.P. Crawford | SS | Sea | 30 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Anthony Volpe | SS | NYA | 24 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Jace Jung | 3B | Det | 24 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Cody Bellinger | OF | NYA | 29 | |
| Nick Castellanos | OF | Phi | 33 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Giancarlo Stanton | OF | NYA | 35 | March 26, 2025:60 Day IL |
| Alek Thomas | OF | Ari | 25 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Jose Berrios | SP | Tor | 30 | |
| Edward Cabrera | SP | Mia | 27 | |
| Max Fried | SP | NYA | 31 | |
| Jackson Jobe | SP | Det | 22 | |
| Davis Martin | SP | ChA | 28 | |
| Bailey Ober | SP | Min | 29 | |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Logan Webb | SP | SF | 28 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Alexis Diaz | RP | Cin | 28 | |
| Raisel Iglesias | RP | Atl | 35 |