| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Pedro Pages | C | StL | 26 | |
| Cal Raleigh | C | Sea | 28 | |
| Willson Contreras | 1B | StL | 32 | |
| Yandy Diaz | 1B | TB | 33 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Gleyber Torres | 2B | Det | 28 | |
| Brice Turang | 2B | Mil | 25 | |
| Bo Bichette | SS | Tor | 27 | |
| Jeremy Pena | SS | Hou | 27 | |
| Masyn Winn | SS | StL | 23 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Isaac Paredes | 3B | Hou | 26 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Jorge Soler | OF | LAA | 32 | |
| George Springer | OF | Tor | 35 | |
| Spencer Steer | OF (1B) | Cin | 27 | |
| Kyle Stowers | OF | Mia | 27 | |
| Christian Yelich | OF | Mil | 33 | |
| Garrett Crochet | SP | Bos | 25 | |
| Luis Gil | SP | NYA | 26 | March 24, 2025:60 Day IL |
| Tanner Houck | SP | Bos | 28 | |
| Mitch Keller | SP | Pit | 29 | |
| Merrill Kelly | SP | Ari | 36 | |
| Nick Lodolo | SP | Cin | 27 | |
| Mike Lorenzen | SP | KC | 33 | |
| Michael McGreevy | SP | StL | 24 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Eduardo Rodriguez | SP | Ari | 32 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Paul Skenes | SP | Pit | 22 | |
| Camilo Doval | RP | SF | 27 | |
| Jeff Hoffman | RP | Tor | 32 |