| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Drake Baldwin | C | Atl | 24 | |
| Jonah Heim | C | Tex | 29 | |
| Keibert Ruiz | C | Was | 26 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Carlos Santana | 1B | Cle | 39 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Tyler Freeman | SS (2B) | Col | 25 | April 13, 2025:10 Day IL |
| Trey Sweeney | SS | Det | N/A | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Alec Bohm | 3B | Phi | 28 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Mark Canha | OF | KC | 36 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Jerar Encarnación | OF | SF | 27 | March 26, 2025:60 Day IL |
| Ian Happ | OF | ChN | 30 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Justin Turner | DH (1B) | ChN | 40 | |
| Shane Baz | SP | TB | 25 | |
| Brayan Bello | SP | Bos | 25 | |
| Ben Brown | SP | ChN | 25 | |
| Pat Corbin | SP | Tex | 35 | |
| Marco Gonzales | SP | Pit | 33 | |
| Kyle Hendricks | SP | LAA | 35 | |
| Adrian Houser | SP | NYN | 32 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Rhett Lowder | SP | Cin | N/A | March 26, 2025:15 Day IL |
| Daniel Lynch | SP (RP) | KC | 28 | |
| Tyler Mahle | SP | Tex | 30 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Martin Perez | SP | ChA | 34 | April 19, 2025:60 Day IL |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Emilio Pagan | RP | Cin | 33 |