| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Bryce Harper | 1B | Phi | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Willy Adames | SS | SF | 29 | |
| Jeremy Pena | SS | Hou | 27 | |
| JJ Wetherholt | SS | StL | 22 | |
| Nolan Arenado | 3B | StL | 34 | |
| Alex Bregman | 3B | Bos | 31 | |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| TJ Friedl | OF | Cin | 29 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Anthony Santander | OF | Tor | 30 | |
| Victor Scott | OF | StL | 24 | |
| George Springer | OF | Tor | 35 | |
| Brayan Bello | SP | Bos | 25 | |
| Luis Castillo | SP | Sea | 32 | |
| Dylan Cease | SP | SD | 29 | |
| Bowden Francis | SP | Tor | 29 | |
| Max Fried | SP | NYA | 31 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Pablo Lopez | SP | Min | 29 | |
| Aaron Nola | SP | Phi | 31 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Drew Rasmussen | SP | TB | 29 | |
| Edwin Diaz | RP | NYN | 31 |