| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Alejandro Kirk | C | Tor | 26 | |
| Tyler Stephenson | C | Cin | 28 | |
| Austin Wells | C | NYA | 25 | |
| Pete Alonso | 1B | NYN | 30 | |
| Ben Rice | 1B | NYA | 26 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Xavier Edwards | SS | Mia | 25 | |
| Dansby Swanson | SS | ChN | 31 | |
| Ramon Urias | SS (3B) | Bal | 30 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Matt Vierling | 3B | Det | 28 | March 27, 2025:10 Day IL |
| Randy Arozarena | OF | Sea | 30 | |
| Corbin Carroll | OF | Ari | 24 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Taylor Ward | OF | LAA | 31 | |
| Osvaldo Bido | SP | Oak | N/A | |
| Griffin Canning | SP | NYN | 28 | |
| Alexander Cobb | SP | Det | 37 | March 27, 2025:15 Day IL |
| Jack Flaherty | SP | Det | 29 | |
| Zac Gallen | SP | Ari | 29 | |
| Bryce Miller | SP | Sea | 26 | |
| Kumar Rocker | SP | Tex | N/A | April 25, 2025:15 Day IL |
| Clarke Schmidt | SP | NYA | 29 | |
| Kodai Senga | SP | NYN | 32 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Trevor Megill | RP | Mil | 31 | |
| Ryan Pressly | RP | ChN | 36 |