| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Alejandro Kirk | C | Tor | 26 | |
| Shea Langeliers | C | Oak | 27 | |
| Ty France | 1B | Min | 30 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Luis Garcia | 2B | Was | 24 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Zach Neto | SS | LAA | 24 | |
| Bobby Witt Jr. | SS | KC | 24 | |
| Nolan Arenado | 3B | StL | 34 | |
| Austin Riley | 3B | Atl | 28 | |
| Lawrence Butler | OF | Oak | 24 | |
| Michael Conforto | OF | LAD | 32 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Lars Nootbaar | OF | StL | 27 | |
| Luis Robert Jr. | OF | ChA | 27 | |
| Anthony Santander | OF | Tor | 30 | |
| Alex Verdugo | OF | Atl | 28 | |
| Griffin Canning | SP | NYN | 28 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Luis Gil | SP | NYA | 26 | March 24, 2025:60 Day IL |
| Tony Gonsolin | SP | LAD | 30 | |
| Seth Lugo | SP | KC | 35 | |
| Bailey Ober | SP | Min | 29 | |
| Robbie Ray | SP | SF | 33 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Chris Sale | SP | Atl | 36 | |
| Tarik Skubal | SP | Det | 28 | |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Simeon Woods Richardson | SP | Min | 24 | |
| Shelby Miller | RP | Ari | 34 | |
| Ryan Pressly | RP | ChN | 36 |