| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Carson Kelly | C | ChN | 30 | |
| Keibert Ruiz | C | Was | 26 | |
| Jac Caglianone | 1B | KC | 22 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Bryce Harper | 1B | Phi | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Ben Rice | 1B | NYA | 26 | |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Zach McKinstry | 2B (3B,OF) | Det | 30 | |
| Anthony Volpe | SS | NYA | 24 | |
| Jacob Wilson | SS | Oak | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Josh Jung | 3B | Tex | 27 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Riley Greene | OF | Det | 24 | |
| Trevor Larnach | OF | Min | 28 | |
| Andy Pages | OF | LAD | 24 | |
| Brent Rooker | OF | Oak | 30 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Mike Yastrzemski | OF | SF | 34 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Pat Corbin | SP | Tex | 35 | |
| Ryan Gusto | SP (RP) | Hou | N/A | |
| Nick Lodolo | SP | Cin | 27 | |
| David Peterson | SP | NYN | 29 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Kodai Senga | SP | NYN | 32 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Justin Verlander | SP | SF | 42 | |
| Bryan Woo | SP | Sea | 25 | |
| Felix Bautista | RP | Bal | 29 | |
| Andres Munoz | RP | Sea | 26 |