| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Bo Naylor | C | Cle | 25 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Luis Arraez | 1B | SD | 28 | |
| Yandy Diaz | 1B | TB | 33 | |
| Marcus Semien | 2B | Tex | 34 | |
| Brice Turang | 2B | Mil | 25 | |
| CJ Abrams | SS | Was | 24 | |
| Xander Bogaerts | SS | SD | 32 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Alec Bohm | 3B | Phi | 28 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Joey Ortiz | 3B (SS) | Mil | 26 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Corbin Carroll | OF | Ari | 24 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Jarren Duran | OF | Bos | 28 | |
| TJ Friedl | OF | Cin | 29 | |
| Steven Kwan | OF | Cle | 27 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Tyler Anderson | SP | LAA | 35 | |
| Kutter Crawford | SP | Bos | 29 | March 24, 2025:15 Day IL |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Charlie Morton | SP | Bal | 41 | |
| Cole Ragans | SP | KC | 27 | |
| Joe Ryan | SP | Min | 28 | |
| Marcus Stroman | SP | NYA | 34 | April 12, 2025:15 Day IL |
| Ranger Suarez | SP | Phi | 29 | March 23, 2025:15 Day IL |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Hayden Wesneski | SP | Hou | 27 | |
| Edwin Diaz | RP | NYN | 31 | |
| Lucas Erceg | RP | KC | 30 | |
| Trevor Megill | RP | Mil | 31 | |
| Kirby Yates | RP | LAD | 38 |