| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Agustin Ramirez | C | Mia | 23 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Nick Kurtz | 1B | Oak | 22 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Michael Toglia | 1B | Col | 26 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Noelvi Marte | 3B | Cin | 23 | |
| Max Muncy | 3B | LAD | 34 | |
| Cam Smith | 3B (OF) | Hou | 22 | |
| Oneil Cruz | OF | Pit | 26 | |
| Adolis Garcia | OF | Tex | 32 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Heliot Ramos | OF | SF | 25 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Daulton Varsho | OF | Tor | 28 | |
| Andrew Abbott | SP | Cin | 25 | |
| Tanner Bibee | SP | Cle | 26 | |
| Matt Boyd | SP | ChN | 34 | |
| Bubba Chandler | SP | Pit | N/A | |
| Zac Gallen | SP | Ari | 29 | |
| Mitch Keller | SP | Pit | 29 | |
| Michael King | SP | SD | 29 | |
| Jack Leiter | SP | Tex | N/A | |
| Pablo Lopez | SP | Min | 29 | |
| Jesus Luzardo | SP | Phi | 27 | |
| Reese Olson | SP | Det | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Tanner Scott | RP | LAD | 30 |