| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Dillon Dingler | C | Det | N/A | |
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Sean Murphy | C | Atl | 30 | |
| Jeimer Candelario | 1B (3B) | Cin | 31 | April 30, 2025:10 Day IL |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Matt Mervis | 1B | Mia | 27 | |
| Ozzie Albies | 2B | Atl | 28 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Mookie Betts | SS | LAD | 32 | |
| Carlos Correa | SS | Min | 30 | |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Isaac Paredes | 3B | Hou | 26 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Ben Williamson | 3B | Sea | N/A | |
| Yordan Alvarez | OF | Hou | 27 | |
| Jasson Dominguez | OF | NYA | 22 | |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Wyatt Langford | OF | Tex | 23 | |
| Christopher Morel | OF | TB | 25 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Ben Brown | SP | ChN | 25 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Nathan Eovaldi | SP | Tex | 35 | |
| Jack Flaherty | SP | Det | 29 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Matthew Liberatore | SP | StL | 25 | |
| Aaron Nola | SP | Phi | 31 | |
| Colin Rea | SP (RP) | ChN | 34 | |
| Luis Severino | SP | Oak | 31 | |
| Brady Singer | SP | Cin | 28 | |
| Shane Smith | SP | ChA | N/A | |
| Trevor Williams | SP | Was | 33 | |
| Yoshinobu Yamamoto | SP | LAD | 26 |