| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Triston Casas | 1B | Bos | 25 | May 03, 2025:10 Day IL |
| Spencer Torkelson | 1B | Det | 25 | |
| Nolan Gorman | 2B | StL | 24 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Masyn Winn | SS | StL | 23 | |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Coby Mayo | 3B | Bal | 23 | |
| Matt Shaw | 3B | ChN | 23 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Mark Vientos | 3B | NYN | 25 | |
| Roman Anthony | OF | Bos | 20 | |
| Kerry Carpenter | OF | Det | 27 | |
| Tommy Edman | OF (2B) | LAD | 29 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Kyle Tucker | OF | ChN | 28 | |
| James Wood | OF | Was | 22 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Shane Baz | SP | TB | 25 | |
| Max Fried | SP | NYA | 31 | |
| MacKenzie Gore | SP | Was | 26 | |
| Hunter Greene | SP | Cin | 25 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Bryce Miller | SP | Sea | 26 | |
| Jose Quintana | SP | Mil | 36 | |
| Drew Rasmussen | SP | TB | 29 | |
| JP Sears | SP | Oak | 29 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Michael Wacha | SP | KC | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| David Bednar | RP | Pit | 30 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Camilo Doval | RP | SF | 27 |