| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Patrick Bailey | C | SF | 25 | |
| Ryan Jeffers | C | Min | 27 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Jake Burger | 1B | Tex | 29 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Jackson Holliday | 2B (SS) | Bal | 21 | |
| Jeremy Pena | SS | Hou | 27 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Rafael Devers | 3B | Bos | 28 | |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Josh Smith | 3B (SS) | Tex | 27 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| Lawrence Butler | OF | Oak | 24 | |
| Kyle Tucker | OF | ChN | 28 | |
| Masataka Yoshida | OF | Bos | 31 | March 27, 2025:10 Day IL |
| Mick Abel | SP | Phi | N/A | |
| Jack Flaherty | SP | Det | 29 | |
| Pablo Lopez | SP | Min | 29 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| José Soriano | SP | LAA | 26 | |
| Framber Valdez | SP | Hou | 31 | |
| Lucas Erceg | RP | KC | 30 | |
| Luke Jackson | RP | Tex | 33 | |
| Orion Kerkering | RP | Phi | N/A | |
| Tanner Scott | RP | LAD | 30 |