| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Alejandro Kirk | C | Tor | 26 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Anthony Rizzo | 1B | NYA | 35 | |
| Willi Castro | 2B (SS,3B) | Min | 28 | April 24, 2025:10 Day IL |
| Brandon Lowe | 2B | TB | 30 | |
| Brice Turang | 2B | Mil | 25 | |
| Gunnar Henderson | SS | Bal | 23 | |
| Alec Bohm | 3B | Phi | 28 | |
| Junior Caminero | 3B | TB | 21 | |
| Manny Machado | 3B | SD | 32 | |
| Oneil Cruz | OF | Pit | 26 | |
| Riley Greene | OF | Det | 24 | |
| Heston Kjerstad | OF | Bal | 26 | |
| Steven Kwan | OF | Cle | 27 | |
| Josh Lowe | OF | TB | 27 | March 29, 2025:10 Day IL |
| Luke Raley | OF (1B) | Sea | 30 | May 01, 2025:15 Day IL-Ab strain |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Zac Gallen | SP | Ari | 29 | |
| Grant Holmes | SP | Atl | N/A | |
| Seth Lugo | SP | KC | 35 | |
| Dustin May | SP | LAD | 27 | |
| Drew Rasmussen | SP | TB | 29 | |
| Paul Skenes | SP | Pit | 22 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Jason Adam | RP | SD | 33 | |
| Edwin Diaz | RP | NYN | 31 | |
| Kenley Jansen | RP | LAA | 37 | |
| Griffin Jax | RP | Min | 30 |