| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| J.T. Realmuto | C | Phi | 34 | |
| Connor Wong | C | Bos | 28 | |
| Colt Keith | 1B (2B) | Det | 23 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Christian Walker | 1B | Hou | 34 | |
| Ozzie Albies | 2B | Atl | 28 | |
| Bo Bichette | SS | Tor | 27 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Trevor Story | SS | Bos | 32 | |
| Trea Turner | SS | Phi | 31 | |
| Nolan Arenado | 3B | StL | 34 | |
| Jarren Duran | OF | Bos | 28 | |
| TJ Friedl | OF | Cin | 29 | |
| Nolan Jones | OF | Cle | 26 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| Christian Yelich | OF | Mil | 33 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Matt Boyd | SP | ChN | 34 | |
| Cody Bradford | SP | Tex | 27 | |
| Taj Bradley | SP | TB | 24 | |
| Garrett Crochet | SP | Bos | 25 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Robbie Ray | SP | SF | 33 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Will Warren | SP | NYA | N/A | |
| Pete Fairbanks | RP | TB | 31 | |
| Ryan Helsley | RP | StL | 30 | |
| Edwin Uceta | RP | TB | 27 |