| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Will Smith | C | LAD | 30 | |
| Luis Arraez | 1B | SD | 28 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Corey Seager | SS | Tex | 31 | April 23, 2025:10 Day IL |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Max Muncy | 3B | LAD | 34 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Evan Carter | OF | Tex | 22 | |
| Jackson Chourio | OF | Mil | 21 | |
| Brenton Doyle | OF | Col | 26 | |
| Lourdes Gurriel | OF | Ari | 31 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Joc Pederson | OF | Tex | 33 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Giancarlo Stanton | OF | NYA | 35 | March 26, 2025:60 Day IL |
| Sandy Alcantara | SP | Mia | 29 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Luis Castillo | SP | Sea | 32 | |
| Nathan Eovaldi | SP | Tex | 35 | |
| Hunter Greene | SP | Cin | 25 | |
| DJ Herz | SP | Was | N/A | March 25, 2025:15 Day IL |
| Shota Imanaga | SP | ChN | 31 | |
| Jesus Luzardo | SP | Phi | 27 | |
| Reese Olson | SP | Det | 25 | |
| Kodai Senga | SP | NYN | 32 | |
| Luis Severino | SP | Oak | 31 | |
| Felix Bautista | RP | Bal | 29 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Ryan Pressly | RP | ChN | 36 |