| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Bo Naylor | C | Cle | 25 | |
| Michael Busch | 1B | ChN | 27 | |
| Yandy Diaz | 1B | TB | 33 | |
| Andrew Vaughn | 1B | ChA | 27 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| J.P. Crawford | SS | Sea | 30 | |
| Dansby Swanson | SS | ChN | 31 | |
| Matt Chapman | 3B | SF | 32 | |
| Ryan McMahon | 3B | Col | 30 | |
| Matt Vierling | 3B | Det | 28 | March 27, 2025:10 Day IL |
| Jo Adell | OF | LAA | 26 | |
| Randy Arozarena | OF | Sea | 30 | |
| Christopher Morel | OF | TB | 25 | |
| Anthony Santander | OF | Tor | 30 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Taylor Ward | OF | LAA | 31 | |
| Chris Bassitt | SP | Tor | 36 | |
| Tanner Houck | SP | Bos | 28 | |
| Mitch Keller | SP | Pit | 29 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| Brady Singer | SP | Cin | 28 | |
| Tarik Skubal | SP | Det | 28 | |
| Justin Steele | SP | ChN | 29 | April 09, 2025:60 Day IL |
| Jameson Taillon | SP | ChN | 33 | |
| Michael Wacha | SP | KC | 33 | |
| Emmanuel Clase | RP | Cle | 27 | |
| Jason Foley | RP | Det | 29 | |
| Raisel Iglesias | RP | Atl | 35 |