| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Tyler Stephenson | C | Cin | 28 | |
| Triston Casas | 1B | Bos | 25 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Thairo Estrada | 2B | Col | 29 | March 27, 2025:60 Day IL |
| Luis Garcia | 2B | Was | 24 | |
| Carlos Correa | SS | Min | 30 | |
| Xavier Edwards | SS | Mia | 25 | |
| Ernie Clement | 3B | Tor | 29 | |
| Josh Jung | 3B | Tex | 27 | |
| Corbin Carroll | OF | Ari | 24 | |
| Dylan Crews | OF | Was | 23 | |
| Michael Harris II | OF | Atl | 24 | |
| Cedric Mullins II | OF | Bal | 30 | |
| Victor Robles | OF | Sea | 27 | April 07, 2025:60 Day IL |
| Seiya Suzuki | OF | ChN | 30 | |
| Fernando Tatis Jr. | OF | SD | 26 | |
| Tanner Bibee | SP | Cle | 26 | |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Corbin Burnes | SP | Ari | 30 | |
| Kutter Crawford | SP | Bos | 29 | March 24, 2025:15 Day IL |
| Jacob deGrom | SP | Tex | 36 | |
| David Festa | SP | Min | N/A | |
| Jared Jones | SP | Pit | 23 | March 27, 2025:60 Day IL |
| Merrill Kelly | SP | Ari | 36 | |
| Freddy Peralta | SP | Mil | 28 | |
| Nick Pivetta | SP | SD | 32 | |
| Chad Green | RP | Tor | 33 | |
| Josh Hader | RP | Hou | 31 | |
| Jordan Romano | RP | Phi | 32 |