| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Austin Wells | C | NYA | 25 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Bryce Harper | 1B | Phi | 32 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Otto Lopez | 2B | Mia | 26 | |
| CJ Abrams | SS | Was | 24 | |
| Mookie Betts | SS | LAD | 32 | |
| Xander Bogaerts | SS | SD | 32 | |
| Zach Neto | SS | LAA | 24 | |
| Masyn Winn | SS | StL | 23 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Miguel Vargas | 3B | ChA | 25 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Jake McCarthy | OF | Ari | 27 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Brandon Nimmo | OF | NYN | 32 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Hayden Birdsong | SP (RP) | SF | N/A | |
| Jackson Jobe | SP | Det | 22 | |
| Tyler Mahle | SP | Tex | 30 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Tobias Myers | SP | Mil | N/A | |
| Bailey Ober | SP | Min | 29 | |
| Cole Ragans | SP | KC | 27 | |
| Kumar Rocker | SP | Tex | N/A | April 25, 2025:15 Day IL |
| Joe Ryan | SP | Min | 28 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Jhoan Duran | RP | Min | 27 | |
| Ben Joyce | RP | LAA | 24 | April 11, 2025:15 Day IL |
| Mason Miller | RP | Oak | 26 | |
| Andres Munoz | RP | Sea | 26 |