| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Edgar Quero | C | ChA | 22 | |
| Will Smith | C | LAD | 30 | |
| Luis Arraez | 1B | SD | 28 | |
| Andrew Vaughn | 1B | ChA | 27 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Bryson Stott | 2B | Phi | 27 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Francisco Lindor | SS | NYN | 31 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Manny Machado | 3B | SD | 32 | |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Riley Greene | OF | Det | 24 | |
| Jake McCarthy | OF | Ari | 27 | |
| Parker Meadows | OF | Det | 25 | March 24, 2025:60 Day IL |
| Christopher Morel | OF | TB | 25 | |
| Cedric Mullins II | OF | Bal | 30 | |
| George Springer | OF | Tor | 35 | |
| Daulton Varsho | OF | Tor | 28 | |
| Chris Bassitt | SP | Tor | 36 | |
| Taj Bradley | SP | TB | 24 | |
| Luis Castillo | SP | Sea | 32 | |
| Dylan Cease | SP | SD | 29 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Tyler Mahle | SP | Tex | 30 | |
| Bryce Miller | SP | Sea | 26 | |
| Ryan Pepiot | SP | TB | 27 | |
| Chris Sale | SP | Atl | 36 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Framber Valdez | SP | Hou | 31 | |
| Logan Webb | SP | SF | 28 | |
| Kenley Jansen | RP | LAA | 37 | |
| Will Vest | RP | Det | 29 | |
| Ryan Walker | RP | SF | N/A |