| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Samuel Basallo | C | Bal | 20 | |
| Shea Langeliers | C | Oak | 27 | |
| Bo Naylor | C | Cle | 25 | |
| Yandy Diaz | 1B | TB | 33 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Marcus Semien | 2B | Tex | 34 | |
| Mookie Betts | SS | LAD | 32 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Matt Shaw | 3B | ChN | 23 | |
| Roman Anthony | OF | Bos | 20 | |
| Randy Arozarena | OF | Sea | 30 | |
| Jordan Beck | OF | Col | 24 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Jasson Dominguez | OF | NYA | 22 | |
| Wyatt Langford | OF | Tex | 23 | |
| Bubba Chandler | SP | Pit | N/A | |
| Jacob deGrom | SP | Tex | 36 | |
| Zac Gallen | SP | Ari | 29 | |
| Hunter Greene | SP | Cin | 25 | |
| Jackson Jobe | SP | Det | 22 | |
| Jack Leiter | SP | Tex | N/A | |
| Lance McCullers | SP | Hou | 31 | March 27, 2025:15 Day IL |
| Andrew Painter | SP | Phi | N/A | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Roki Sasaki | SP | LAD | 23 | |
| José Alvarado | RP | Phi | 29 | |
| Edwin Diaz | RP | NYN | 31 | |
| Trevor Megill | RP | Mil | 31 |