| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Sean Murphy | C | Atl | 30 | |
| Pedro Pages | C | StL | 26 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Triston Casas | 1B | Bos | 25 | |
| Ty France | 1B | Min | 30 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Matt McLain | 2B | Cin | 25 | |
| Jeff McNeil | 2B | NYN | 33 | |
| Bo Bichette | SS | Tor | 27 | |
| Carson Williams | SS | TB | 21 | |
| Masyn Winn | SS | StL | 23 | |
| Matt Chapman | 3B | SF | 32 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Mark Vientos | 3B | NYN | 25 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Oneil Cruz | OF | Pit | 26 | |
| Trent Grisham | OF | NYA | 28 | |
| Brent Rooker | OF | Oak | 30 | |
| Kyle Stowers | OF | Mia | 27 | |
| Jordan Walker | OF | StL | 22 | |
| Walker Buehler | SP | Bos | 30 | May 02, 2025:15 Day IL-Shoulder |
| Max Fried | SP | NYA | 31 | |
| Lucas Giolito | SP | Bos | 30 | |
| Mike Lorenzen | SP | KC | 33 | |
| Dustin May | SP | LAD | 27 | |
| Max Meyer | SP | Mia | 26 | |
| Mitchell Parker | SP | Was | 25 | |
| Drew Rasmussen | SP | TB | 29 | |
| Tomoyuki Sugano | SP | Bal | 35 | |
| Carlos Estevez | RP | KC | 32 | |
| Mason Miller | RP | Oak | 26 |