| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Samuel Basallo | C | Bal | 20 | |
| Sean Murphy | C | Atl | 30 | |
| Pete Alonso | 1B | NYN | 30 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Bryce Eldridge | 1B | SF | 20 | |
| Matt Olson | 1B | Atl | 31 | |
| Ben Rice | 1B | NYA | 26 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Hyeseong Kim | 2B | LAD | 26 | |
| Brandon Lowe | 2B | TB | 30 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Dansby Swanson | SS | ChN | 31 | |
| Sebastian Walcott | SS | Tex | 19 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Kerry Carpenter | OF | Det | 27 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Seiya Suzuki | OF | ChN | 30 | |
| Mike Trout | OF | LAA | 33 | May 02, 2025:10 Day IL |
| James Wood | OF | Was | 22 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Kris Bubic | SP | KC | 27 | |
| MacKenzie Gore | SP | Was | 26 | |
| George Kirby | SP | Sea | 27 | March 27, 2025:15 Day IL |
| Zebby Matthews | SP | Min | N/A | |
| Reese Olson | SP | Det | 25 | |
| Nick Pivetta | SP | SD | 32 | |
| Cole Ragans | SP | KC | 27 | |
| Drew Rasmussen | SP | TB | 29 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Shane Smith | SP | ChA | N/A | |
| Gavin Williams | SP | Cle | 25 | |
| Jeff Hoffman | RP | Tor | 32 | |
| Emilio Pagan | RP | Cin | 33 |