| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Alejandro Kirk | C | Tor | 26 | |
| Sean Murphy | C | Atl | 30 | September 08, 2025:10 Day IL |
| Adley Rutschman | C | Bal | 27 | August 21, 2025:10 Day IL |
| Carlos Santana | 1B | ChN | 39 | |
| Christian Walker | 1B | Hou | 34 | |
| Jose Altuve | 2B (OF) | Hou | 35 | |
| Brice Turang | 2B | Mil | 25 | |
| J.P. Crawford | SS | Sea | 30 | |
| Corey Seager | SS | Tex | 31 | August 29, 2025:10 Day IL |
| Masyn Winn | SS | StL | 23 | September 13, 2025:10 Day IL |
| Alex Bregman | 3B | Bos | 31 | |
| Maikel Garcia | 3B (2B,SS,OF) | KC | 25 | |
| Yoan Moncada | 3B | LAA | 30 | |
| Jorge Polanco | 3B (2B) | Sea | 32 | |
| Eugenio Suarez | 3B | Sea | 34 | |
| Wilyer Abreu | OF | Bos | 26 | August 21, 2025:10 Day IL |
| Nick Castellanos | OF | Phi | 33 | |
| Ian Happ | OF | ChN | 31 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Ramón Laureano | OF | SD | 31 | |
| Gavin Sheets | OF (1B) | SD | 29 | |
| Kyle Stowers | OF | Mia | 27 | August 17, 2025:10 Day IL |
| Christian Yelich | OF | Mil | 33 | |
| Nathan Eovaldi | SP | Tex | 35 | August 27, 2025:15 Day IL |
| Lucas Giolito | SP | Bos | 31 | |
| Shota Imanaga | SP | ChN | 32 | |
| Merrill Kelly | SP | Tex | 36 | |
| Yusei Kikuchi | SP | LAA | 34 | |
| Eric Lauer | SP (RP) | Tor | 30 | |
| Brady Singer | SP | Cin | 29 | |
| Ranger Suarez | SP | Phi | 30 | |
| Camilo Doval | RP | NYA | 28 | |
| Pete Fairbanks | RP | TB | 31 | |
| Kenley Jansen | RP | LAA | 37 |