| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Jonah Heim | C | Tex | 29 | |
| Ryan Jeffers | C | Min | 27 | |
| Dalton Rushing | C | LAD | 24 | |
| Deyvison De Los Santos | 1B | Mia | 21 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Isiah Kiner-Falefa | SS | Pit | 30 | |
| Anthony Volpe | SS | NYA | 24 | |
| Ke'Bryan Hayes | 3B | Pit | 28 | |
| Josh Jung | 3B | Tex | 27 | |
| Matt Shaw | 3B | ChN | 23 | |
| Randy Arozarena | OF | Sea | 30 | |
| Jackson Chourio | OF | Mil | 21 | |
| Max Clark | OF | Det | 20 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Lars Nootbaar | OF | StL | 27 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Brent Rooker | OF | Oak | 30 | |
| Jose Berrios | SP | Tor | 30 | |
| Luis Castillo | SP | Sea | 32 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Max Fried | SP | NYA | 31 | |
| Sonny Gray | SP | StL | 35 | |
| Seth Lugo | SP | KC | 35 | |
| Tyler Mahle | SP | Tex | 30 | |
| Aaron Nola | SP | Phi | 31 | |
| Bryan Woo | SP | Sea | 25 | |
| Carlos Estevez | RP | KC | 32 | |
| Tanner Scott | RP | LAD | 30 | |
| Devin Williams | RP | NYA | 30 |