| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Patrick Bailey | C | SF | 25 | |
| Cal Raleigh | C | Sea | 28 | |
| Yandy Diaz | 1B | TB | 33 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Michael Toglia | 1B | Col | 26 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Jeremy Pena | SS | Hou | 27 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Manny Machado | 3B | SD | 32 | |
| Noelvi Marte | 3B | Cin | 23 | |
| Max Muncy | 3B | LAD | 34 | |
| Brenton Doyle | OF | Col | 26 | |
| Adolis Garcia | OF | Tex | 32 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Andy Pages | OF | LAD | 24 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Anthony Santander | OF | Tor | 30 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Alex Verdugo | OF | Atl | 28 | |
| Brayan Bello | SP | Bos | 25 | |
| Jacob deGrom | SP | Tex | 36 | |
| Jack Flaherty | SP | Det | 29 | |
| Nick Lodolo | SP | Cin | 27 | |
| Mitchell Parker | SP | Was | 25 | |
| David Peterson | SP | NYN | 29 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| José Soriano | SP | LAA | 26 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Alexis Diaz | RP | Cin | 28 | |
| Andres Munoz | RP | Sea | 26 | |
| Ryan Walker | RP | SF | N/A |