| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Gabriel Moreno | C | Ari | 25 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Christian Walker | 1B | Hou | 34 | |
| Wilmer Flores | 2B | SF | 33 | |
| Luke Keaschall | 2B | Min | 22 | April 26, 2025:10 Day IL |
| Bryson Stott | 2B | Phi | 27 | |
| Gleyber Torres | 2B | Det | 28 | |
| J.P. Crawford | SS | Sea | 30 | |
| Xavier Edwards | SS | Mia | 25 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Royce Lewis | 3B | Min | 25 | March 27, 2025:15 Day IL-Ab strain |
| Dylan Moore | 3B (2B,OF) | Sea | 32 | April 29, 2025:10 Day IL |
| Jorge Polanco | 3B | Sea | 31 | |
| Adolis Garcia | OF | Tex | 32 | |
| Lourdes Gurriel | OF | Ari | 31 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Aaron Judge | OF | NYA | 33 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Kyle Tucker | OF | ChN | 28 | |
| Kris Bubic | SP | KC | 27 | |
| Chase Burns | SP | Cin | 22 | |
| Dylan Cease | SP | SD | 29 | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Max Fried | SP | NYA | 31 | |
| Logan Henderson | SP | Mil | N/A | |
| Rhett Lowder | SP | Cin | N/A | March 26, 2025:15 Day IL |
| Cristopher Sanchez | SP | Phi | 28 | |
| Clarke Schmidt | SP | NYA | 29 | |
| JP Sears | SP | Oak | 29 | |
| Zack Wheeler | SP | Phi | 34 | |
| Edwin Diaz | RP | NYN | 31 | |
| Pete Fairbanks | RP | TB | 31 |