| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Alejandro Kirk | C | Tor | 26 | |
| Triston Casas | 1B | Bos | 25 | May 03, 2025:60 Day IL |
| Willson Contreras | 1B | StL | 33 | |
| Nico Hoerner | 2B | ChN | 28 | |
| Konnor Griffin | SS | Pit | 19 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Masyn Winn | SS | StL | 23 | |
| Bobby Witt Jr. | SS | KC | 25 | |
| Josh Jung | 3B | Tex | 27 | |
| Yoan Moncada | 3B | LAA | 30 | June 02, 2025:10 Day IL |
| Jasson Dominguez | OF | NYA | 22 | |
| Brenton Doyle | OF | Col | 27 | |
| Michael Harris II | OF | Atl | 24 | |
| Heliot Ramos | OF | SF | 25 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Chandler Simpson | OF | TB | 24 | |
| Chris Bassitt | SP | Tor | 36 | |
| Brayan Bello | SP | Bos | 26 | |
| Tanner Bibee | SP | Cle | 26 | |
| Taj Bradley | SP | TB | 24 | |
| Zach Eflin | SP | Bal | 31 | June 30, 2025:15 Day IL |
| Pablo Lopez | SP | Min | 29 | June 05, 2025:60 Day IL |
| Chad Patrick | SP | Mil | N/A | |
| Ryan Pepiot | SP | TB | 27 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Clarke Schmidt | SP | NYA | 29 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:60 Day IL-Ab strain |
| Mike Soroka | SP | Was | 27 | |
| Ryan Weathers | SP | Mia | 25 | June 09, 2025:60 Day IL |
| Aroldis Chapman | RP | Bos | 37 | |
| Ryan Helsley | RP | StL | 30 |