| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Triston Casas | 1B | Bos | 25 | May 03, 2025:60 Day IL |
| Willson Contreras | 1B | StL | 33 | |
| Nico Hoerner | 2B (SS) | ChN | 28 | |
| Konnor Griffin | SS | Pit | 19 | |
| Gunnar Henderson | SS | Bal | 24 | |
| Arjun Nimmala | SS | Tor | 19 | |
| Luis Pena | SS | Mil | 18 | |
| Masyn Winn | SS | StL | 23 | September 13, 2025:10 Day IL |
| Bobby Witt Jr. | SS | KC | 25 | |
| Josh Jung | 3B | Tex | 27 | |
| Yoan Moncada | 3B | LAA | 30 | |
| Jasson Dominguez | OF | NYA | 22 | |
| Brenton Doyle | OF | Col | 27 | |
| Michael Harris II | OF | Atl | 24 | |
| Lazaro Montes | OF | Sea | 20 | |
| Heliot Ramos | OF | SF | 26 | |
| Bryan Reynolds | OF | Pit | 30 | |
| Julio Rodriguez | OF | Sea | 24 | |
| Chandler Simpson | OF | TB | 24 | |
| Chris Bassitt | SP | Tor | 36 | |
| Brayan Bello | SP | Bos | 26 | |
| Tanner Bibee | SP | Cle | 26 | |
| Kyle Bradish | SP | Bal | 29 | |
| Taj Bradley | SP | Min | 24 | |
| Zach Eflin | SP | Bal | 31 | July 31, 2025:60 Day IL |
| Pablo Lopez | SP | Min | 29 | |
| Ryan Pepiot | SP | TB | 28 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Clarke Schmidt | SP | NYA | 29 | July 04, 2025:60 Day IL |
| Blake Snell | SP | LAD | 32 | |
| Aroldis Chapman | RP | Bos | 37 | |
| Ryan Helsley | RP | NYN | 31 |