| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Agustin Ramirez | C | Mia | 23 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Carlos Santana | 1B | Cle | 39 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Jake Cronenworth | 2B | SD | 31 | April 11, 2025:10 Day IL |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Mookie Betts | SS | LAD | 32 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Connor Norby | 3B | Mia | 24 | |
| Matt Shaw | 3B | ChN | 23 | |
| Roman Anthony | OF | Bos | 20 | |
| Jordan Beck | OF | Col | 24 | |
| Jarren Duran | OF | Bos | 28 | |
| Tyler O'Neill | OF | Bal | 29 | April 26, 2025:10 Day IL |
| Anthony Santander | OF | Tor | 30 | |
| Matt Wallner | OF | Min | 27 | April 17, 2025:10 Day IL |
| Marcell Ozuna | DH | Atl | 34 | |
| Ronel Blanco | SP | Hou | 31 | |
| Bubba Chandler | SP | Pit | N/A | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Andrew Painter | SP | Phi | N/A | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Robbie Ray | SP | SF | 33 | |
| Cristopher Sanchez | SP | Phi | 28 | |
| Luis Severino | SP | Oak | 31 | |
| Brady Singer | SP | Cin | 28 | |
| José Soriano | SP | LAA | 26 | |
| Framber Valdez | SP | Hou | 31 | |
| Gavin Williams | SP | Cle | 25 | |
| Devin Williams | RP | NYA | 30 |