| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Shea Langeliers | C | Oak | 27 | |
| Sean Murphy | C | Atl | 30 | |
| Jonathan Aranda | 1B | TB | 26 | |
| Bryce Eldridge | 1B | SF | 20 | |
| Vladimir Guerrero Jr. | 1B | Tor | 26 | |
| Matt Olson | 1B | Atl | 31 | |
| Ben Rice | 1B | NYA | 26 | |
| Jazz Chisholm Jr. | 2B | NYA | 27 | May 02, 2025:15 Day IL-Oblique |
| Brandon Lowe | 2B | TB | 30 | |
| Elly De La Cruz | SS | Cin | 23 | |
| Dansby Swanson | SS | ChN | 31 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Matt Shaw | 3B | ChN | 23 | |
| Luis Urias | 3B (2B) | Oak | 27 | |
| Lawrence Butler | OF | Oak | 24 | |
| Oneil Cruz | OF | Pit | 26 | |
| Hunter Goodman | OF (C) | Col | 25 | |
| Ian Happ | OF | ChN | 30 | |
| Josh Lowe | OF | TB | 27 | March 29, 2025:10 Day IL |
| Kameron Misner | OF | TB | N/A | |
| James Wood | OF | Was | 22 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Kris Bubic | SP | KC | 27 | |
| Luis Castillo | SP | Sea | 32 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Tony Gonsolin | SP | LAD | 30 | |
| Grant Holmes | SP | Atl | N/A | |
| Zebby Matthews | SP | Min | N/A | |
| Reese Olson | SP | Det | 25 | |
| Drew Rasmussen | SP | TB | 29 | |
| Joe Ryan | SP | Min | 28 | |
| Shelby Miller | RP | Ari | 34 | |
| Andres Munoz | RP | Sea | 26 | |
| Emilio Pagan | RP | Cin | 33 |