| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Yainer Diaz | C | Hou | 26 | |
| Will Smith | C | LAD | 30 | |
| Bryce Harper | 1B | Phi | 32 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Travis Bazzana | 2B | Cle | 22 | |
| Andrés Gimenez | 2B | Tor | 26 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Marcus Semien | 2B | Tex | 34 | |
| Xander Bogaerts | SS | SD | 32 | |
| Trea Turner | SS | Phi | 31 | |
| JJ Wetherholt | SS | StL | 22 | |
| Nolan Arenado | 3B | StL | 34 | |
| Jorge Polanco | 3B | Sea | 31 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Randy Arozarena | OF | Sea | 30 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Austin Hays | OF | Cin | 29 | May 02, 2025:10 Day IL |
| Bryan Reynolds | OF | Pit | 30 | |
| Anthony Santander | OF | Tor | 30 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Jordan Walker | OF | StL | 22 | |
| Luis Castillo | SP | Sea | 32 | |
| Bowden Francis | SP | Tor | 29 | |
| Logan Gilbert | SP | Sea | 27 | April 26, 2025:15 Day IL |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Aaron Nola | SP | Phi | 31 | |
| Bailey Ober | SP | Min | 29 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Carlos Rodon | SP | NYA | 32 | |
| Jeffrey Springs | SP | Oak | 32 | |
| Michael Wacha | SP | KC | 33 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Jeff Hoffman | RP | Tor | 32 | |
| Ryan Pressly | RP | ChN | 36 |