| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Mil | 27 | |
| Gabriel Moreno | C | Ari | 25 | |
| Jeimer Candelario | 1B (3B) | Cin | 31 | April 30, 2025:10 Day IL |
| Rhys Hoskins | 1B | Mil | 32 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Christian Walker | 1B | Hou | 34 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Ketel Marte | 2B | Ari | 31 | |
| Carlos Correa | SS | Min | 30 | |
| Zach Neto | SS | LAA | 24 | |
| Alec Bohm | 3B | Phi | 28 | |
| Matt Vierling | 3B | Det | 28 | March 27, 2025:10 Day IL |
| Randy Arozarena | OF | Sea | 30 | |
| Cody Bellinger | OF | NYA | 29 | |
| Alec Burleson | OF (1B) | StL | 26 | |
| TJ Friedl | OF | Cin | 29 | |
| Jurickson Profar | OF | Atl | 32 | |
| Ceddanne Rafaela | OF | Bos | 24 | |
| Kyle Tucker | OF | ChN | 28 | |
| Osvaldo Bido | SP | Oak | N/A | |
| Ronel Blanco | SP | Hou | 31 | |
| Gerrit Cole | SP | NYA | 34 | March 22, 2025:60 Day IL |
| Yu Darvish | SP | SD | 38 | March 27, 2025:15 Day IL |
| Nathan Eovaldi | SP | Tex | 35 | |
| Erick Fedde | SP | StL | 32 | |
| Jack Flaherty | SP | Det | 29 | |
| Bowden Francis | SP | Tor | 29 | |
| Shota Imanaga | SP | ChN | 31 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Andrew Painter | SP | Phi | N/A | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| Paul Skenes | SP | Pit | 22 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Randy Vasquez | SP | SD | 26 |