| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Cal Raleigh | C | Sea | 28 | |
| Austin Wynns | C | Cin | 34 | |
| Colt Keith | 1B (2B) | Det | 23 | |
| Spencer Torkelson | 1B | Det | 25 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Wilmer Flores | 2B | SF | 33 | |
| Hyeseong Kim | 2B | LAD | 26 | |
| Brice Turang | 2B | Mil | 25 | |
| CJ Abrams | SS | Was | 24 | |
| Xavier Edwards | SS | Mia | 25 | |
| Kyren Paris | SS (2B,OF) | LAA | 23 | |
| Jace Jung | 3B | Det | 24 | |
| Ryan McMahon | 3B | Col | 30 | |
| Jordan Westburg | 3B (2B) | Bal | 26 | April 28, 2025:10 Day IL |
| Jackson Chourio | OF | Mil | 21 | |
| Trent Grisham | OF | NYA | 28 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Aaron Judge | OF | NYA | 33 | |
| Brent Rooker | OF | Oak | 30 | |
| Mike Yastrzemski | OF | SF | 34 | |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Taj Bradley | SP | TB | 24 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Hunter Dobbins | SP | Bos | N/A | |
| Zach Eflin | SP | Bal | 31 | April 09, 2025:15 Day IL |
| Kevin Gausman | SP | Tor | 34 | |
| Andrew Heaney | SP | Pit | 33 | |
| Ben Lively | SP | Cle | 33 | |
| Bryce Miller | SP | Sea | 26 | |
| Framber Valdez | SP | Hou | 31 | |
| Yoshinobu Yamamoto | SP | LAD | 26 | |
| Ryan Helsley | RP | StL | 30 | |
| Emilio Pagan | RP | Cin | 33 | |
| Robert Suarez | RP | SD | 34 |