| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Bo Naylor | C | Cle | 25 | |
| Pedro Pages | C | StL | 26 | |
| Tyler Stephenson | C | Cin | 28 | |
| Rhys Hoskins | 1B | Mil | 32 | |
| Nathaniel Lowe | 1B | Was | 29 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Nolan Gorman | 2B | StL | 24 | |
| Gavin Lux | 2B (OF) | Cin | 27 | |
| Mookie Betts | SS | LAD | 32 | |
| Jose Caballero | SS (3B,OF) | TB | 28 | |
| Masyn Winn | SS | StL | 23 | |
| Matt Chapman | 3B | SF | 32 | |
| Jarren Duran | OF | Bos | 28 | |
| Ian Happ | OF | ChN | 30 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Kyle Tucker | OF | ChN | 28 | |
| Shohei Ohtani | DH ,SP | LAD | 30 | |
| Andrew Abbott | SP | Cin | 25 | |
| Osvaldo Bido | SP | Oak | N/A | |
| Ben Brown | SP | ChN | 25 | |
| Jacob deGrom | SP | Tex | 36 | |
| Jack Flaherty | SP | Det | 29 | |
| Mike Lorenzen | SP | KC | 33 | |
| Casey Mize | SP | Det | 28 | |
| Luis Ortiz | SP | Cle | 26 | |
| Nick Pivetta | SP | SD | 32 | |
| Chris Sale | SP | Atl | 36 | |
| Tarik Skubal | SP | Det | 28 | |
| Ryan Weathers | SP | Mia | 25 | March 27, 2025:15 Day IL |
| Luke Weaver | SP (RP) | NYA | 31 | |
| Trevor Megill | RP | Mil | 31 | |
| Shelby Miller | RP | Ari | 34 |