| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Francisco Álvarez | C | NYN | 23 | |
| Keibert Ruiz | C | Was | 26 | |
| Christian Encarnacion-Strand | 1B | Cin | 25 | April 17, 2025:10 Day IL |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Kristian Campbell | 2B (OF) | Bos | 22 | |
| Tyler Fitzgerald | 2B | SF | 27 | May 01, 2025:10 Day IL |
| Jeff McNeil | 2B | NYN | 33 | |
| Willy Adames | SS | SF | 29 | |
| Trevor Story | SS | Bos | 32 | |
| Josh Jung | 3B | Tex | 27 | |
| Connor Norby | 3B | Mia | 24 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Roman Anthony | OF | Bos | 20 | |
| Dylan Crews | OF | Was | 23 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Sal Frelick | OF | Mil | 25 | |
| Michael Harris II | OF | Atl | 24 | |
| Heliot Ramos | OF | SF | 25 | |
| Victor Scott | OF | StL | 24 | |
| Tim Tawa | OF (2B) | Ari | N/A | |
| Hunter Brown | SP | Hou | 26 | |
| Tylor Megill | SP | NYN | 29 | |
| Aaron Nola | SP | Phi | 31 | |
| Jose Quintana | SP | Mil | 36 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Cristopher Sanchez | SP | Phi | 28 | |
| Spencer Schwellenbach | SP | Atl | 24 | |
| Bryan Woo | SP | Sea | 25 | |
| José Alvarado | RP | Phi | 29 | |
| Camilo Doval | RP | SF | 27 | |
| Robert Suarez | RP | SD | 34 | |
| Ryan Walker | RP | SF | N/A |