| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Logan O'Hoppe | C | LAA | 25 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Ryan O'Hearn | 1B (OF) | Bal | 31 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Nolan Gorman | 2B | StL | 24 | |
| Gleyber Torres | 2B | Det | 28 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Xander Bogaerts | SS | SD | 32 | |
| Trea Turner | SS | Phi | 31 | |
| JJ Wetherholt | SS | StL | 22 | |
| Maikel Garcia | 3B (2B,OF) | KC | 25 | |
| Jose Ramirez | 3B | Cle | 32 | |
| Colton Cowser | OF | Bal | 25 | March 31, 2025:60 Day IL-Left thumb fracture |
| Lourdes Gurriel | OF | Ari | 31 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Andy Pages | OF | LAD | 24 | |
| Kyle Schwarber | OF | Phi | 32 | |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Kyle Tucker | OF | ChN | 28 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Bowden Francis | SP | Tor | 29 | |
| Tyler Glasnow | SP | LAD | 31 | April 29, 2025:15 Day IL |
| Sonny Gray | SP | StL | 35 | |
| Matthew Liberatore | SP | StL | 25 | |
| Sean Manaea | SP | NYN | 33 | March 27, 2025:60 Day IL |
| Aaron Nola | SP | Phi | 31 | |
| Bailey Ober | SP | Min | 29 | |
| Brandon Pfaadt | SP | Ari | 26 | |
| Carlos Rodon | SP | NYA | 32 | |
| Brandon Woodruff | SP | Mil | 32 | March 27, 2025:15 Day IL |
| Emmanuel Clase | RP | Cle | 27 | |
| Andres Munoz | RP | Sea | 26 | |
| Ryan Pressly | RP | ChN | 36 |