| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Logan O'Hoppe | C | LAA | 25 | |
| Triston Casas | 1B | Bos | 25 | |
| Freddie Freeman | 1B | LAD | 35 | |
| Tyler Soderstrom | 1B (OF) | Oak | 23 | |
| Zack Gelof | 2B | Oak | 25 | March 23, 2025:15 Day IL |
| Brandon Lowe | 2B | TB | 30 | |
| Jeff McNeil | 2B | NYN | 33 | |
| Dansby Swanson | SS | ChN | 31 | |
| Trea Turner | SS | Phi | 31 | |
| Manny Machado | 3B | SD | 32 | |
| Matt Shaw | 3B | ChN | 23 | |
| Ben Williamson | 3B | Sea | N/A | |
| Roman Anthony | OF | Bos | 20 | |
| Evan Carter | OF | Tex | 22 | |
| Trent Grisham | OF | NYA | 28 | |
| Jung Hoo Lee | OF | SF | 26 | |
| Jackson Merrill | OF | SD | 22 | April 08, 2025:10 Day IL |
| Mike Trout | OF | LAA | 33 | |
| Alex Verdugo | OF | Atl | 28 | |
| Taylor Ward | OF | LAA | 31 | |
| James Wood | OF | Was | 22 | |
| Shane Baz | SP | TB | 25 | |
| Zac Gallen | SP | Ari | 29 | |
| Grant Holmes | SP | Atl | N/A | |
| Shane McClanahan | SP | TB | 28 | March 26, 2025:60 Day IL-Ab strain |
| Max Meyer | SP | Mia | 26 | |
| Aaron Nola | SP | Phi | 31 | |
| Max Scherzer | SP | Tor | 40 | March 30, 2025:15 Day IL-Thumb |
| José Soriano | SP | LAA | 26 | |
| Randy Vasquez | SP | SD | 26 | |
| Bryan Woo | SP | Sea | 25 | |
| Josh Hader | RP | Hou | 31 | |
| Mason Miller | RP | Oak | 26 |