| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Joey Bart | C | Pit | 28 | |
| Salvador Perez | C (C,1B) | KC | 34 | |
| Paul Goldschmidt | 1B | NYA | 37 | |
| Carlos Santana | 1B | Cle | 39 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Brendan Donovan | 2B (SS,OF) | StL | 28 | |
| Otto Lopez | 2B | Mia | 26 | |
| Trea Turner | SS | Phi | 31 | |
| Masyn Winn | SS | StL | 23 | |
| Rafael Devers | 3B | Bos | 28 | |
| Ryan McMahon | 3B | Col | 30 | |
| TJ Friedl | OF | Cin | 29 | |
| Teoscar Hernández | OF | LAD | 32 | |
| Steven Kwan | OF | Cle | 27 | |
| Cedric Mullins II | OF | Bal | 30 | |
| Lars Nootbaar | OF | StL | 27 | |
| Jurickson Profar | OF | Atl | 32 | |
| Victor Robles | OF | Sea | 27 | April 07, 2025:60 Day IL |
| Pavin Smith | OF (1B) | Ari | 29 | |
| Lane Thomas | OF | Cle | 29 | April 22, 2025:10 Day IL |
| Eli White | OF | Atl | 30 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Shane Bieber | SP | Cle | 29 | March 27, 2025:15 Day IL |
| Kris Bubic | SP | KC | 27 | |
| Corbin Burnes | SP | Ari | 30 | |
| Nestor Cortes Jr. | SP | Mil | 30 | April 06, 2025:60 Day IL-Left elbow flexor strain |
| Shota Imanaga | SP | ChN | 31 | |
| Jake Irvin | SP | Was | 28 | |
| Jackson Jobe | SP | Det | 22 | |
| Yusei Kikuchi | SP | LAA | 33 | |
| Grayson Rodriguez | SP | Bal | 25 | March 27, 2025:60 Day IL |
| Chris Sale | SP | Atl | 36 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Steven Matz | RP | StL | 33 |