| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Ivan Herrera | C | StL | 24 | April 07, 2025:15 Day IL-Knee |
| Pedro Pages | C | StL | 26 | |
| Keibert Ruiz | C | Was | 26 | |
| Kyle Manzardo | 1B | Cle | 24 | |
| Vinnie Pasquantino | 1B | KC | 27 | |
| Nolan Schanuel | 1B | LAA | 23 | |
| Nico Hoerner | 2B | ChN | 27 | |
| Brandon Lowe | 2B | TB | 30 | |
| Marcus Semien | 2B | Tex | 34 | |
| Adael Amador | SS (2B) | Col | N/A | |
| Xander Bogaerts | SS | SD | 32 | |
| Masyn Winn | SS | StL | 23 | |
| Nolan Arenado | 3B | StL | 34 | |
| Connor Norby | 3B | Mia | 24 | |
| Kerry Carpenter | OF | Det | 27 | |
| TJ Friedl | OF | Cin | 29 | |
| Trevor Larnach | OF | Min | 28 | |
| Christopher Morel | OF | TB | 25 | |
| Brandon Nimmo | OF | NYN | 32 | |
| Kyle Stowers | OF | Mia | 27 | |
| Colby Thomas | OF | Oak | 24 | |
| Mike Trout | OF | LAA | 33 | |
| Spencer Arrighetti | SP | Hou | N/A | April 08, 2025:15 Day IL |
| Ronel Blanco | SP | Hou | 31 | |
| Hunter Brown | SP | Hou | 26 | |
| Luis Castillo | SP | Sea | 32 | |
| Pat Corbin | SP | Tex | 35 | |
| Erick Fedde | SP | StL | 32 | |
| Zack Littell | SP | TB | 29 | |
| Nick Lodolo | SP | Cin | 27 | |
| Blake Snell | SP | LAD | 32 | April 06, 2025:15 Day IL-Ab strain |
| Hayden Wesneski | SP | Hou | 27 | |
| Felix Bautista | RP | Bal | 29 | |
| Mason Miller | RP | Oak | 26 |