| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Miguel Amaya | C | ChN | 26 | |
| Samuel Basallo | C | Bal | 20 | |
| Shea Langeliers | C | Oak | 27 | |
| Ryan Mountcastle | 1B | Bal | 28 | |
| Jose Altuve | 2B (OF) | Hou | 34 | |
| Romy Gonzalez | 2B (1B) | Bos | 28 | |
| Jonathan India | 2B (3B,OF) | KC | 28 | |
| Javier Baez | SS (3B,OF) | Det | 32 | |
| Xavier Edwards | SS | Mia | 25 | |
| Marcelo Mayer | SS | Bos | 22 | |
| Ezequiel Tovar | SS | Col | 23 | April 19, 2025:10 Day IL |
| Nolan Arenado | 3B | StL | 34 | |
| Caleb Durbin | 3B | Mil | 25 | |
| Mark Vientos | 3B | NYN | 25 | |
| Wilyer Abreu | OF | Bos | 25 | |
| Yordan Alvarez | OF | Hou | 27 | |
| Jordan Beck | OF | Col | 24 | |
| Cody Bellinger | OF | NYA | 29 | |
| Pete Crow-Armstrong | OF | ChN | 23 | |
| Adolis Garcia | OF | Tex | 32 | |
| Michael Harris II | OF | Atl | 24 | |
| Christian Yelich | OF | Mil | 33 | |
| Sandy Alcantara | SP | Mia | 29 | |
| Brayan Bello | SP | Bos | 25 | |
| Luis Castillo | SP | Sea | 32 | |
| MacKenzie Gore | SP | Was | 26 | |
| Freddy Peralta | SP | Mil | 28 | |
| Eury Perez | SP | Mia | 22 | February 20, 2025:60 Day IL |
| Joe Ryan | SP | Min | 28 | |
| Roki Sasaki | SP | LAD | 23 | |
| Spencer Strider | SP | Atl | 26 | April 21, 2025:15 Day IL |
| Felix Bautista | RP | Bal | 29 | |
| Jhoan Duran | RP | Min | 27 | |
| Devin Williams | RP | NYA | 30 |