| Position | Starters | Team | Opponents |
| C | Logan O'Hoppe | LAA | Tor(3) Bal(3) |
| 1B | Michael Busch | ChN | SF(3) @NYN(3) |
| 2B (OF) | Jose Altuve | Hou | @Mil(3) Cin(3) |
| SS | Francisco Lindor | NYN | @Ari(3) ChN(3) |
| 3B | Mark Vientos | NYN | @Ari(3) ChN(3) |
| OF | JJ Bleday | Oak | Sea(3) NYA(3) |
| OF | Aaron Judge | NYA | SD(3) @Oak(3) |
| OF | James Wood | Was | Cle(3) StL(3) |
| DH | Jorge Polanco | Sea | @Oak(3) Tor(3) |
| Position | 1st Backup | Team | Opponents |
| C | Dillon Dingler | Det | @Col(3) Tex(3) |
| 1B | Ryan Mountcastle | Bal | @Min(3) @LAA(3) |
| 2B | Tyler Fitzgerald | SF | @ChN(3) @Min(3) |
| SS | Geraldo Perdomo | Ari | NYN(3) LAD(4) |
| 3B | Ben Williamson | Sea | @Oak(3) Tor(3) |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| DH | Kameron Misner | TB | Phi(3) Mil(3) |
| Position | Bench | Team | Opponents |
| C | Ethan Salas | SD | @NYA(3) @Col(3) |
| SS | Colson Montgomery | ChA | @KC(4) Mia(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Logan Webb | SF | @ChN(3) @Min(3) | This Saturday at Min (Chris Paddack) |
| 2nd SP | JP Sears | Oak | Sea(3) NYA(3) | This Saturday vs NYA (Will Warren) |
| 3rd SP | Andrew Heaney | Pit | @StL(3) Atl(3) | This Saturday vs Atl (AJ Smith-Shawver) |
| 4th SP | Seth Lugo | KC | ChA(4) Bos(3) | This Tuesday vs ChA (Sean Burke) |
| 5th SP | Sonny Gray | StL | Pit(3) @Was(3) | This Wednesday vs Pit (Mitch Keller) |
| 6th SP | Davis Martin | ChA | @KC(4) Mia(3) | This Thursday at KC (Kris Bubic) |
| 7th SP | Jake Irvin | Was | Cle(3) StL(3) | This Monday vs Cle (Luis Ortiz) |
| 8th SP | Andre Pallante | StL | Pit(3) @Was(3) | This Saturday at Was (MacKenzie Gore) |
| 9th SP | George Kirby | Sea | @Oak(3) Tor(3) | Has Not Played Yet |
| 10th SP | Michael McGreevy | StL | Pit(3) @Was(3) | Has Not Played Yet |
| 11th SP | Andrew Painter | Phi | @TB(3) @Cle(3) | Has Not Played Yet |
| 1st RP | Camilo Doval | SF | @ChN(3) @Min(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Logan Evans | Sea | @Oak(3) Tor(3) | This Saturday vs Tor (Bowden Francis) |
| Position | Injured List | Team | Opponents |
| SP | Gerrit Cole | NYA | SD(3) @Oak(3) |