| Position | Starters | Team | Opponents |
| C | Sean Murphy | Atl | Cin(4) @Pit(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | Elly De La Cruz | Cin | @Atl(4) @Hou(3) |
| 3B | Jose Ramirez | Cle | @Was(3) Phi(3) |
| OF | Jackson Chourio | Mil | Hou(3) @TB(3) |
| OF | Jarren Duran | Bos | Tex(3) @KC(3) |
| OF | Kyle Tucker | ChN | SF(3) @NYN(3) |
| DH (1B,OF) | Pavin Smith | Ari | NYN(3) LAD(4) |
| Position | 1st Backup | Team | Opponents |
| C | Carson Kelly | ChN | SF(3) @NYN(3) |
| 1B (OF) | Ryan O'Hearn | Bal | @Min(3) @LAA(3) |
| 2B | Brandon Lowe | TB | Phi(3) Mil(3) |
| SS | Masyn Winn | StL | Pit(3) @Was(3) |
| 3B (OF) | Cam Smith | Hou | @Mil(3) Cin(3) |
| OF | Jasson Dominguez | NYA | SD(3) @Oak(3) |
| DH (OF,2B) | Gavin Lux | Cin | @Atl(4) @Hou(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Francisco Álvarez | NYN | @Ari(3) ChN(3) |
| OF | Jorge Soler | LAA | Tor(3) Bal(3) |
| Position | 3rd Backup | Team | Opponents |
| OF (C) | Hunter Goodman | Col | Det(3) SD(3) |
| Position | Bench | Team | Opponents |
| SS (3B,OF) | Javier Baez | Det | @Col(3) Tex(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Spencer Schwellenbach | Atl | Cin(4) @Pit(3) | This Thursday vs Cin (Nick Lodolo) |
| 2nd SP | Dustin May | LAD | @Mia(3) @Ari(4) | This Saturday at Ari (Corbin Burnes) |
| 3rd SP | Casey Mize | Det | @Col(3) Tex(3) | This Wednesday at Col (Kyle Freeland) |
| 4th SP | Hayden Wesneski | Hou | @Mil(3) Cin(3) |
This Tuesday at Mil (Chad Patrick)
This Wednesday at Mil (Quinn Priester) |
| 5th SP | Tanner Bibee | Cle | @Was(3) Phi(3) | This Saturday vs Phi (Ranger Suarez) |
| 6th SP | Corbin Burnes | Ari | NYN(3) LAD(4) | This Saturday vs LAD (Dustin May) |
| 7th SP | Sandy Alcantara | Mia | LAD(3) @ChA(3) | This Monday vs LAD (TBD) |
| 1st RP | Jeff Hoffman | Tor | @LAA(3) @Sea(3) | Last Pitched Friday May 2nd |
| 2nd RP | Kyle Finnegan | Was | Cle(3) StL(3) | Last Pitched Thursday May 1st |
| 3rd RP | Emilio Pagan | Cin | @Atl(4) @Hou(3) | Last Pitched Friday May 2nd |
| 4th RP | David Bednar | Pit | @StL(3) Atl(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| SP | Spencer Strider | Atl | Cin(4) @Pit(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| OF | Jackson Merrill | SD | @NYA(3) @Col(3) |