| Position | Starters | Team | Opponents |
| C | Agustin Ramirez | Mia | LAD(3) @ChA(3) |
| 1B (OF) | Tyler Soderstrom | Oak | Sea(3) NYA(3) |
| 2B | Marcus Semien | Tex | @Bos(3) @Det(3) |
| SS | Willy Adames | SF | @ChN(3) @Min(3) |
| 3B | Alex Bregman | Bos | Tex(3) @KC(3) |
| OF | Yordan Alvarez | Hou | @Mil(3) Cin(3) |
| OF | Heliot Ramos | SF | @ChN(3) @Min(3) |
| OF | Christian Yelich | Mil | Hou(3) @TB(3) |
| DH | Freddie Freeman | LAD | @Mia(3) @Ari(4) |
| Position | 1st Backup | Team | Opponents |
| C | Austin Wells | NYA | SD(3) @Oak(3) |
| 1B | Matt Mervis | Mia | LAD(3) @ChA(3) |
| 2B | Bryson Stott | Phi | @TB(3) @Cle(3) |
| SS | Jordan Lawlar | Ari | NYN(3) LAD(4) |
| 3B | Ke'Bryan Hayes | Pit | @StL(3) Atl(3) |
| OF | Roman Anthony | Bos | Tex(3) @KC(3) |
| DH | Triston Casas | Bos | Tex(3) @KC(3) |
| Position | 2nd Backup | Team | Opponents |
| C | J.T. Realmuto | Phi | @TB(3) @Cle(3) |
| 1B | Bryce Eldridge | SF | @ChN(3) @Min(3) |
| 2B | Otto Lopez | Mia | LAD(3) @ChA(3) |
| OF | Alex Verdugo | Atl | Cin(4) @Pit(3) |
| Position | Bench | Team | Opponents |
| OF | Andy Pages | LAD | @Mia(3) @Ari(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Cole Ragans | KC | ChA(4) Bos(3) |
This Monday vs ChA (Shane Smith)
This Saturday vs Bos (Hunter Dobbins) |
| 2nd SP | Bubba Chandler | Pit | @StL(3) Atl(3) | Has Not Played Yet |
| 3rd SP | Cristopher Sanchez | Phi | @TB(3) @Cle(3) | This Wednesday at TB (Shane Baz) |
| 4th SP | Taj Bradley | TB | Phi(3) Mil(3) | This Saturday vs Mil (Freddy Peralta) |
| 5th SP | Matt Boyd | ChN | SF(3) @NYN(3) | This Monday vs SF (Landen Roupp) |
| 6th SP | Max Meyer | Mia | LAD(3) @ChA(3) | This Friday at ChA (Bryse Wilson) |
| 7th SP | José Soriano | LAA | Tor(3) Bal(3) | This Thursday vs Tor (Chris Bassitt) |
| 8th SP | Gunnar Hoglund | Oak | Sea(3) NYA(3) | This Wednesday vs Sea (Bryan Woo) |
| 1st RP | Felix Bautista | Bal | @Min(3) @LAA(3) | Last Pitched Friday May 2nd |
| 2nd RP | José Alvarado | Phi | @TB(3) @Cle(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Opponents |
| OF | Matt Wallner | Min | Bal(3) SF(3) |
| SP | Shane McClanahan | TB | Phi(3) Mil(3) |
| SP | Grayson Rodriguez | Bal | @Min(3) @LAA(3) |