| Position | Starters | Team | Opponents |
| C | Yainer Diaz | Hou | @Mil(3) Cin(3) |
| 1B | Paul Goldschmidt | NYA | SD(3) @Oak(3) |
| 2B (3B,OF) | Zach McKinstry | Det | @Col(3) Tex(3) |
| SS | J.P. Crawford | Sea | @Oak(3) Tor(3) |
| 3B | Junior Caminero | TB | Phi(3) Mil(3) |
| OF | Wilyer Abreu | Bos | Tex(3) @KC(3) |
| OF | Randy Arozarena | Sea | @Oak(3) Tor(3) |
| OF | Corbin Carroll | Ari | NYN(3) LAD(4) |
| DH | Michael Harris II | Atl | Cin(4) @Pit(3) |
| Position | 1st Backup | Team | Opponents |
| C | Keibert Ruiz | Was | Cle(3) StL(3) |
| 1B | Luis Arraez | SD | @NYA(3) @Col(3) |
| 2B | Matt McLain | Cin | @Atl(4) @Hou(3) |
| SS | Xander Bogaerts | SD | @NYA(3) @Col(3) |
| OF | Chandler Simpson | TB | Phi(3) Mil(3) |
| DH | Michael Toglia | Col | Det(3) SD(3) |
| Position | 2nd Backup | Team | Opponents |
| 3B | Matt Shaw | ChN | SF(3) @NYN(3) |
| Position | Bench | Team | Opponents |
| 1B | Jac Caglianone | KC | ChA(4) Bos(3) |
| 1B | Deyvison De Los Santos | Mia | LAD(3) @ChA(3) |
| 2B | Luisangel Acuna | NYN | @Ari(3) ChN(3) |
| 2B | Christian Moore | LAA | Tor(3) Bal(3) |
| SS | Carson Williams | TB | Phi(3) Mil(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Robbie Ray | SF | @ChN(3) @Min(3) | This Wednesday at ChN (Ben Brown) |
| 2nd SP | Luis Castillo | Sea | @Oak(3) Tor(3) | This Friday vs Tor (Kevin Gausman) |
| 3rd SP | Chris Sale | Atl | Cin(4) @Pit(3) | This Tuesday vs Cin (Andrew Abbott) |
| 4th SP | Freddy Peralta | Mil | Hou(3) @TB(3) | This Saturday at TB (Taj Bradley) |
| 5th SP | Joe Ryan | Min | Bal(3) SF(3) | This Thursday vs Bal (Tomoyuki Sugano) |
| 6th SP | Brayan Bello | Bos | Tex(3) @KC(3) | This Friday at KC (Mike Lorenzen) |
| 7th SP | Kris Bubic | KC | ChA(4) Bos(3) | This Thursday vs ChA (Davis Martin) |
| 8th SP | Bailey Ober | Min | Bal(3) SF(3) | This Friday vs SF (Jordan Hicks) |
| 1st RP | Andres Munoz | Sea | @Oak(3) Tor(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Raisel Iglesias | Atl | Cin(4) @Pit(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| OF | Mike Trout | LAA | Tor(3) Bal(3) |
| 3B | Royce Lewis | Min | Bal(3) SF(3) |
| SS | Ezequiel Tovar | Col | Det(3) SD(3) |