| Position | Starters | Team | Opponents |
| C | Adley Rutschman | Bal | @Min(3) @LAA(3) |
| 1B | Vladimir Guerrero Jr. | Tor | @LAA(3) @Sea(3) |
| 2B | Ketel Marte | Ari | NYN(3) LAD(4) |
| SS | Gunnar Henderson | Bal | @Min(3) @LAA(3) |
| 3B | Matt Chapman | SF | @ChN(3) @Min(3) |
| OF | Lawrence Butler | Oak | Sea(3) NYA(3) |
| OF | Oneil Cruz | Pit | @StL(3) Atl(3) |
| OF | Juan Soto | NYN | @Ari(3) ChN(3) |
| DH | Riley Greene | Det | @Col(3) Tex(3) |
| Position | 1st Backup | Team | Opponents |
| C | Gabriel Moreno | Ari | NYN(3) LAD(4) |
| 1B | Nathaniel Lowe | Was | Cle(3) StL(3) |
| 2B (3B,SS) | Gabriel Arias | Cle | @Was(3) Phi(3) |
| SS | Dansby Swanson | ChN | SF(3) @NYN(3) |
| 3B | Ryan McMahon | Col | Det(3) SD(3) |
| OF | Trent Grisham | NYA | SD(3) @Oak(3) |
| DH | Sal Frelick | Mil | Hou(3) @TB(3) |
| Position | 2nd Backup | Team | Opponents |
| 2B | Andrés Gimenez | Tor | @LAA(3) @Sea(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Hunter Greene | Cin | @Atl(4) @Hou(3) | This Wednesday at Atl (Grant Holmes) |
| 2nd SP | Bryan Woo | Sea | @Oak(3) Tor(3) | This Wednesday at Oak (Gunnar Hoglund) |
| 3rd SP | Griffin Canning | NYN | @Ari(3) ChN(3) | This Monday at Ari (TBD) |
| 4th SP | MacKenzie Gore | Was | Cle(3) StL(3) | This Saturday vs StL (Andre Pallante) |
| 5th SP | Carlos Rodon | NYA | SD(3) @Oak(3) | This Monday vs SD (Nick Pivetta) |
| 6th SP | Jack Flaherty | Det | @Col(3) Tex(3) | This Friday vs Tex (Pat Corbin) |
| 7th SP | Randy Vasquez | SD | @NYA(3) @Col(3) | This Friday at Col (Bradley Blalock) |
| 8th SP | Ryan Pepiot | TB | Phi(3) Mil(3) | This Thursday vs Phi (Jesus Luzardo) |
| 9th SP | Reese Olson | Det | @Col(3) Tex(3) | This Saturday vs Tex (Jacob deGrom) |
| 10th SP | Yusei Kikuchi | LAA | Tor(3) Bal(3) | This Wednesday vs Tor (Jose Berrios) |
| 11th SP | Eduardo Rodriguez | Ari | NYN(3) LAD(4) | This Friday vs LAD (Roki Sasaki) |
| 12th SP | Tanner Houck | Bos | Tex(3) @KC(3) | This Thursday vs Tex (Jack Leiter) |
| 1st RP | Ryan Pressly | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| 2nd RP | Abner Uribe | Mil | Hou(3) @TB(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| OF | Josh Lowe | TB | Phi(3) Mil(3) |
| SP | Brandon Woodruff | Mil | Hou(3) @TB(3) |
| SP | Eury Perez | Mia | LAD(3) @ChA(3) |