| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Ben Rice | NYA | SD(3) @Oak(3) |
| 2B (3B) | Luis Rengifo | LAA | Tor(3) Bal(3) |
| SS | Zach Neto | LAA | Tor(3) Bal(3) |
| 3B | Austin Riley | Atl | Cin(4) @Pit(3) |
| OF | Wyatt Langford | Tex | @Bos(3) @Det(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| OF | Kyle Schwarber | Phi | @TB(3) @Cle(3) |
| DH | Kerry Carpenter | Det | @Col(3) Tex(3) |
| Position | 1st Backup | Team | Opponents |
| C | Joey Bart | Pit | @StL(3) Atl(3) |
| 1B | Yandy Diaz | TB | Phi(3) Mil(3) |
| 2B (OF) | Rob Refsnyder | Bos | Tex(3) @KC(3) |
| SS | Trevor Story | Bos | Tex(3) @KC(3) |
| 3B | Isaac Paredes | Hou | @Mil(3) Cin(3) |
| OF | Kyle Stowers | Mia | LAD(3) @ChA(3) |
| DH | Mike Yastrzemski | SF | @ChN(3) @Min(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Victor Scott | StL | Pit(3) @Was(3) |
| DH | Ceddanne Rafaela | Bos | Tex(3) @KC(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Tyler Mahle | Tex | @Bos(3) @Det(3) | This Wednesday at Bos (Lucas Giolito) |
| 2nd SP | Tomoyuki Sugano | Bal | @Min(3) @LAA(3) | This Thursday at Min (Joe Ryan) |
| 3rd SP | David Peterson | NYN | @Ari(3) ChN(3) | This Tuesday at Ari (Zac Gallen) |
| 4th SP | Jeffrey Springs | Oak | Sea(3) NYA(3) | This Tuesday vs Sea (Emerson Hancock) |
| 5th SP | Jose Berrios | Tor | @LAA(3) @Sea(3) | This Wednesday at LAA (Yusei Kikuchi) |
| 6th SP | Nick Lodolo | Cin | @Atl(4) @Hou(3) | This Thursday at Atl (Spencer Schwellenbach) |
| 7th SP | Andrew Abbott | Cin | @Atl(4) @Hou(3) |
This Tuesday at Atl (Chris Sale)
This Saturday at Hou (Lance McCullers) |
| 8th SP | Dylan Cease | SD | @NYA(3) @Col(3) | This Wednesday at NYA (Carlos Carrasco) |
| 1st RP | Carlos Estevez | KC | ChA(4) Bos(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Josh Hader | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 3rd RP | Ryan Helsley | StL | Pit(3) @Was(3) | Last Pitched Friday May 2nd |
| 4th RP (SP) | Grant Holman | Oak | Sea(3) NYA(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| SP | Justin Steele | ChN | SF(3) @NYN(3) |
| OF (2B) | Tommy Edman | LAD | @Mia(3) @Ari(4) |