| Position | Starters | Team | Opponents |
| C | Tyler Stephenson | Cin | @Atl(4) @Hou(3) |
| 1B | Matt Olson | Atl | Cin(4) @Pit(3) |
| 2B (OF) | Kristian Campbell | Bos | Tex(3) @KC(3) |
| SS | Bo Bichette | Tor | @LAA(3) @Sea(3) |
| 3B (OF,SS) | Jose Caballero | TB | Phi(3) Mil(3) |
| OF | Cody Bellinger | NYA | SD(3) @Oak(3) |
| OF | Byron Buxton | Min | Bal(3) SF(3) |
| OF | Jung Hoo Lee | SF | @ChN(3) @Min(3) |
| DH | Marcell Ozuna | Atl | Cin(4) @Pit(3) |
| Position | 1st Backup | Team | Opponents |
| C | Jonah Heim | Tex | @Bos(3) @Det(3) |
| 1B | Rhys Hoskins | Mil | Hou(3) @TB(3) |
| 2B | Ozzie Albies | Atl | Cin(4) @Pit(3) |
| SS | Carlos Correa | Min | Bal(3) SF(3) |
| 3B | Matt Vierling | Det | @Col(3) Tex(3) |
| OF | Nick Castellanos | Phi | @TB(3) @Cle(3) |
| DH (1B,OF) | Alec Burleson | StL | Pit(3) @Was(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Alejandro Kirk | Tor | @LAA(3) @Sea(3) |
| 3B | Max Muncy | LAD | @Mia(3) @Ari(4) |
| OF | Evan Carter | Tex | @Bos(3) @Det(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Paul Skenes | Pit | @StL(3) Atl(3) | This Tuesday at StL (Matthew Liberatore) |
| 2nd SP | Framber Valdez | Hou | @Mil(3) Cin(3) | This Friday vs Cin (Nick Martinez) |
| 3rd SP | Max Fried | NYA | SD(3) @Oak(3) | This Friday at Oak (Osvaldo Bido) |
| 4th SP | Zac Gallen | Ari | NYN(3) LAD(4) | This Tuesday vs NYN (David Peterson) |
| 5th SP | Kevin Gausman | Tor | @LAA(3) @Sea(3) | This Friday at Sea (Luis Castillo) |
| 6th SP | Shane Baz | TB | Phi(3) Mil(3) | This Wednesday vs Phi (Cristopher Sanchez) |
| 7th SP | Brandon Pfaadt | Ari | NYN(3) LAD(4) | This Thursday vs LAD (Yoshinobu Yamamoto) |
| 8th SP | Spencer Arrighetti | Hou | @Mil(3) Cin(3) | Last Pitched Saturday April 5th |
| 9th SP | Mitch Keller | Pit | @StL(3) Atl(3) | This Wednesday at StL (Sonny Gray) |
| 1st RP | Robert Suarez | SD | @NYA(3) @Col(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Ryan Walker | SF | @ChN(3) @Min(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Kenley Jansen | LAA | Tor(3) Bal(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| 1B | Christian Encarnacion-Strand | Cin | @Atl(4) @Hou(3) |
| 2B | Thairo Estrada | Col | Det(3) SD(3) |
| SP | Jared Jones | Pit | @StL(3) Atl(3) |