| Position | Starters | Team | Opponents |
| C | Sean Murphy | Atl | Cin(4) @Pit(3) |
| 1B | Pete Alonso | NYN | @Ari(3) ChN(3) |
| 2B | Marcus Semien | Tex | @Bos(3) @Det(3) |
| SS | Dansby Swanson | ChN | SF(3) @NYN(3) |
| 3B | Manny Machado | SD | @NYA(3) @Col(3) |
| OF | Pete Crow-Armstrong | ChN | SF(3) @NYN(3) |
| OF | Brenton Doyle | Col | Det(3) SD(3) |
| OF | Julio Rodriguez | Sea | @Oak(3) Tor(3) |
| DH | Shohei Ohtani | LAD | @Mia(3) @Ari(4) |
| Position | 1st Backup | Team | Opponents |
| C | Yainer Diaz | Hou | @Mil(3) Cin(3) |
| 1B | Jonathan Aranda | TB | Phi(3) Mil(3) |
| SS | Xavier Edwards | Mia | LAD(3) @ChA(3) |
| 3B | Ben Williamson | Sea | @Oak(3) Tor(3) |
| OF | Alex Verdugo | Atl | Cin(4) @Pit(3) |
| DH | Adolis Garcia | Tex | @Bos(3) @Det(3) |
| Position | 2nd Backup | Team | Opponents |
| 1B | Bryce Eldridge | SF | @ChN(3) @Min(3) |
| 2B | Travis Bazzana | Cle | @Was(3) Phi(3) |
| OF | Kameron Misner | TB | Phi(3) Mil(3) |
| Position | Bench | Team | Opponents |
| 2B (1B) | Romy Gonzalez | Bos | Tex(3) @KC(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Shota Imanaga | ChN | SF(3) @NYN(3) | This Saturday at NYN (Tylor Megill) |
| 2nd SP | Jacob deGrom | Tex | @Bos(3) @Det(3) | This Saturday at Det (Reese Olson) |
| 3rd SP | Freddy Peralta | Mil | Hou(3) @TB(3) | This Saturday at TB (Taj Bradley) |
| 4th SP | MacKenzie Gore | Was | Cle(3) StL(3) | This Saturday vs StL (Andre Pallante) |
| 5th SP | Shane Smith | ChA | @KC(4) Mia(3) |
This Monday at KC (Cole Ragans)
This Saturday vs Mia (Edward Cabrera) |
| 6th SP | Gavin Williams | Cle | @Was(3) Phi(3) | This Friday vs Phi (Aaron Nola) |
| 7th SP | Sandy Alcantara | Mia | LAD(3) @ChA(3) | This Monday vs LAD (TBD) |
| 8th SP | Jackson Jobe | Det | @Col(3) Tex(3) | This Tuesday at Col (Chase Dollander) |
| 9th SP | Lucas Giolito | Bos | Tex(3) @KC(3) | This Wednesday vs Tex (Tyler Mahle) |
| 1st RP | Aroldis Chapman | Bos | Tex(3) @KC(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Pete Fairbanks | TB | Phi(3) Mil(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Trevor Megill | Mil | Hou(3) @TB(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| OF | Matt Wallner | Min | Bal(3) SF(3) |
| SP | Shane McClanahan | TB | Phi(3) Mil(3) |
| SP | Eury Perez | Mia | LAD(3) @ChA(3) |