| Position | Starters | Team | Opponents |
| C | Cal Raleigh | Sea | @Oak(3) Tor(3) |
| 1B | Michael Busch | ChN | SF(3) @NYN(3) |
| SS | Zach Neto | LAA | Tor(3) Bal(3) |
| 3B | Junior Caminero | TB | Phi(3) Mil(3) |
| OF | Wyatt Langford | Tex | @Bos(3) @Det(3) |
| OF | Fernando Tatis Jr. | SD | @NYA(3) @Col(3) |
| OF | James Wood | Was | Cle(3) StL(3) |
| DH | Trevor Story | Bos | Tex(3) @KC(3) |
| Position | 1st Backup | Team | Opponents |
| C | Joey Bart | Pit | @StL(3) Atl(3) |
| 1B | Nick Kurtz | Oak | Sea(3) NYA(3) |
| SS (2B,3B) | Gabriel Arias | Cle | @Was(3) Phi(3) |
| 3B | Isaac Paredes | Hou | @Mil(3) Cin(3) |
| OF | Dylan Crews | Was | Cle(3) StL(3) |
| DH | Royce Lewis | Min | Bal(3) SF(3) |
| Position | 2nd Backup | Team | Opponents |
| SS | Jordan Lawlar | Ari | NYN(3) LAD(4) |
| DH (OF,3B) | Cam Smith | Hou | @Mil(3) Cin(3) |
| Position | Bench | Team | Opponents |
| SS | Marcelo Mayer | Bos | Tex(3) @KC(3) |
| 3B (2B,SS) | Chase Meidroth | ChA | @KC(4) Mia(3) |
| OF | Daulton Varsho | Tor | @LAA(3) @Sea(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Mitchell Parker | Was | Cle(3) StL(3) | This Wednesday vs Cle (Logan Allen) |
| 2nd SP | Tyler Mahle | Tex | @Bos(3) @Det(3) | This Wednesday at Bos (Lucas Giolito) |
| 3rd SP | Casey Mize | Det | @Col(3) Tex(3) | This Wednesday at Col (Kyle Freeland) |
| 4th SP | Luis Severino | Oak | Sea(3) NYA(3) | This Monday vs Sea (Bryce Miller) |
| 5th SP | Drew Rasmussen | TB | Phi(3) Mil(3) | This Tuesday vs Phi (Zack Wheeler) |
| 6th SP | Roki Sasaki | LAD | @Mia(3) @Ari(4) | This Friday at Ari (Eduardo Rodriguez) |
| 7th SP | Griffin Canning | NYN | @Ari(3) ChN(3) | This Monday at Ari (TBD) |
| 8th SP | Ranger Suarez | Phi | @TB(3) @Cle(3) | This Saturday at Cle (Tanner Bibee) |
| 1st RP | Ryan Helsley | StL | Pit(3) @Was(3) | Last Pitched Friday May 2nd |
| 2nd RP | Emilio Pagan | Cin | @Atl(4) @Hou(3) | Last Pitched Friday May 2nd |
| 3rd RP (SP) | Luke Weaver | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| 4th RP | Devin Williams | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Opponents |
| 2B | Jazz Chisholm Jr. | NYA | SD(3) @Oak(3) |